Jörn Dengjel
Biographical sketch:
Jörn Dengjel studied biochemistry at the Universities of Potsdam and Tübingen and obtained his PhD in 2005 at the Department of Immunology, at the University of Tübingen studying the regulation of MHC-II peptide presentation using mass spectrometry. After a short stay in industry, he moved 2006 with an EMBO long-term fellowship to the Center for Experimental Bioinformatics at University of Southern Denmark, focusing on proteomics and autophagy. 2009 he was recruited as junior fellow to the Freiburg Institute for Advanced Studies where he setup his group. 2013 he became Professor for Medical Proteome Research at the Department of Dermatology at the Medical Center, University of Freiburg. Since 2016 he is Professor for Biochemistry and Cell Biology at the Department of Biology at the University of Fribourg working on the regulation of protein homeostasis employing mass spectrometry-based proteomics.
Selected publications:
Leytens, A., Benitez-Fernandez, R., Jimenez-Garcia, C., Roubaty, C., Stumpe, M., Boya, P., and Dengjel, J. (2024). Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy. Autophagy, 1-16.
Sankar, D.S., Kaeser-Pebernard, S., Vionnet, C., Favre, S., de Oliveira Marchioro, L., Pillet, B., Zhou, J., Stumpe, M., Kovacs, W.J., Kressler, D., Antonioli, M., Fimia, G.M., and Dengjel, J. (2024). The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization. Cell Rep 43, 114689.
Kallergi, E., Siva Sankar, D., Matera, A., Kolaxi, A., Paolicelli, R.C., Dengjel, J., and Nikoletopoulou, V. (2023). Profiling of purified autophagic vesicle degradome in the maturing and aging brain. Neuron 111, 2329-2347 e2327.
Zhou, J., Rasmussen, N.L., Olsvik, H.L., Akimov, V., Hu, Z., Evjen, G., Kaeser-Pebernard, S., Sankar, D.S., Roubaty, C., Verlhac, P., van de Beck, N., Reggiori, F., Abudu, Y.P., Blagoev, B., Lamark, T., Johansen, T., and Dengjel, J. (2023). TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1. J Cell Biol 222.
Kaeser-Pebernard, S., Vionnet, C., Mari, M., Sankar, D.S., Hu, Z., Roubaty, C., Martinez-Martinez, E., Zhao, H., Spuch-Calvar, M., Petri-Fink, A., Rainer, G., Steinberg, F., Reggiori, F., and Dengjel, J. (2022). mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1. Nat Commun 13, 4685.
Hu Z, Sankar DS, Vu B, Leytens A, Vionnet C, Wu W, Stumpe M, Martinez-Martinez E, Stork B, Dengjel J (2021) ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy. Cell Rep 36: 109762
Martinez-Martinez E, Tolle R, Donauer J, Gretzmeier C, Bruckner-Tuderman L, Dengjel J (2021) Increased abundance of Cbl E3 ligases alters PDGFR signaling in recessive dystrophic epidermolysis bullosa. Matrix Biol 103-104: 58-73
Berberich, B, Thriene, K, Gretzmeier, C, Kuhl, T, Bayer, H, Athanasiou, I, Rafei-Shamsabadi, DA, Bruckner-Tuderman, L, Nystrom, A, Kiritsi, D, & Dengjel, J (2020). Proteomic Profiling of Fibroblasts Isolated from Chronic Wounds Identifies Disease-Relevant Signaling Pathways. J Invest Dermatol 140:2280-2290 e2284.
