Mentor beneficiaries, together with their lab members and an international community of mTOR researchers, met at the 3^rd edition of the TOR de France symposium that was held in Nice in October 2023 (https://www.tor-de-france.fr/). After fruitful discussions, it became evident that the Mentor program will be organized in six work packages (WPs) performing complementary research (WP1-3), training (WP4), management (WP5) and outreach (WP6).

Mentor WP Interaction scheme

The Research WPs will consider different aspects from novel mTOR signaling elements to therapeutic evaluation and prognostic studies in models of mTORopathies and human cohorts.

Multidisciplinary Training will enable Doctoral Candidates to benefit from international exchanges, industry secondments, patient observation and clinical training, strong local research environments. The training modules will cover Schools on Drug Discovery, Metabolic Control of Cell growth, Pathophysiology of mTORopathies.

The overall goal will be to train a new generation of scientists though approaches of biology, chemistry and medicine to provide a new molecular and cellular cartography of mTORopathies, as well as propose personalized treatments to patients  

Scheme of the mTOR network as well as manifestations of monogenic diseases. Positive (green) and negative (orange) growth regulators. HME: hemimegalencephaly