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Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 16:02:052026-07-21 16:02:05Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling

Deep Proteome Profiling of Primary Skin Fibroblasts

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 16:00:292026-07-21 16:00:29Deep Proteome Profiling of Primary Skin Fibroblasts

Combination of in vivo and in vitro phosphoproteomics determines the PP2A target repertoire on proteome scale

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 15:58:392026-07-21 15:59:44Combination of in vivo and in vitro phosphoproteomics determines the PP2A target repertoire on proteome scale

TORC1 autonomously controls its spatial partitioning via the Rag GTPase tether Tco89

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 15:57:312026-07-21 15:57:31TORC1 autonomously controls its spatial partitioning via the Rag GTPase tether Tco89

EGO complex at 20: The Rag GTPase-TORC1 nutrient-sensing blueprint

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 15:56:362026-07-21 15:56:36EGO complex at 20: The Rag GTPase-TORC1 nutrient-sensing blueprint

The nitrogen starvation-induced inhibitor Rts3 restrains Sit4/PP6 to gate quiescence downstream of TORC1

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 15:54:562026-07-21 15:55:47The nitrogen starvation-induced inhibitor Rts3 restrains Sit4/PP6 to gate quiescence downstream of TORC1

Tuberous sclerosis complex-associated kidney disease in children

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 15:48:092026-07-21 15:53:34Tuberous sclerosis complex-associated kidney disease in children

Characteristics of patients with autosomal polycystic kidney disease reaching kidney failure by age 40

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 15:47:122026-07-21 15:47:12Characteristics of patients with autosomal polycystic kidney disease reaching kidney failure by age 40

KDIGO 2025 ADPKD guideline through pediatric eyes

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 15:44:352026-07-21 15:44:55KDIGO 2025 ADPKD guideline through pediatric eyes

Blueprint for clinical N-of-1 strategies with off-label precision treatments in monogenic epilepsies

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 15:05:132026-07-21 15:05:13Blueprint for clinical N-of-1 strategies with off-label precision treatments in monogenic epilepsies

Continuous outcome estimation in N-of-1 trials for accelerated decision-making

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 15:00:182026-07-21 15:00:18Continuous outcome estimation in N-of-1 trials for accelerated decision-making

Continuous outcome estimation in N-of-1 trials for accelerated decision-making

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 14:59:222026-07-21 14:59:22Continuous outcome estimation in N-of-1 trials for accelerated decision-making

On the coupling between a basic FcRn mechanism and target-mediated disposition of antibodies

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 14:58:132026-07-21 14:58:13On the coupling between a basic FcRn mechanism and target-mediated disposition of antibodies

A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 14:56:532026-07-21 14:56:53A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2

High-Quality In Vivo Chemical Probes for Protein Kinases Disclosed in 2024

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 14:56:012026-07-21 14:56:01High-Quality In Vivo Chemical Probes for Protein Kinases Disclosed in 2024

A Warm Welcome to MedChem: The Frontiers in Medicinal Chemistry 2025

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 14:25:352026-07-21 14:27:59A Warm Welcome to MedChem: The Frontiers in Medicinal Chemistry 2025

SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 14:23:422026-07-21 14:23:42SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids

https://pubmed.ncbi.nlm.nih.gov/39799571/

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 14:22:132026-07-21 14:22:13https://pubmed.ncbi.nlm.nih.gov/39799571/

Protocol for the visualization of pRps6-positive cells in larval zebrafish brains using whole-mount immunofluorescence and light-sheet microscopy

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 14:20:492026-07-21 14:20:49Protocol for the visualization of pRps6-positive cells in larval zebrafish brains using whole-mount immunofluorescence and light-sheet microscopy

Challenges and hopes for treatment of anxiety disorder in the autistic population

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 14:19:222026-07-21 14:19:22Challenges and hopes for treatment of anxiety disorder in the autistic population

Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 14:14:542026-07-21 14:14:54Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia

Mosaic human cortical organoids model mTOR-related focal cortical dysplasia through DEPDC5 deletion

https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 14:13:202026-07-21 14:13:20Mosaic human cortical organoids model mTOR-related focal cortical dysplasia through DEPDC5 deletion

mTOR controls ependymal cell differentiation by targeting the alternative cell cycle and centrosomal proteins

https://pubmed.ncbi.nlm.nih.gov/40307619/
https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png 0 0 Magdalena TORTYNA https://mentor-program.eu/wp-content/uploads/2024/12/mentor-logo@2x-300x47.png Magdalena TORTYNA2026-07-21 14:10:452026-07-21 14:10:45mTOR controls ependymal cell differentiation by targeting the alternative cell cycle and centrosomal proteins

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The MENTOR Doctoral Network

Université Paris-Cité (UPCité)
85 Boulevard Saint-Germain,
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Coordinator :

Mario Pende

Project manager :

Magdalena Tortyna

Funded by the European Union under the grant agreement No 101168624. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency (REA). Neither the European Union nor the granting authority can be held responsible for them.

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