DC 11: Seema Ouhadi
Seema Ouhadi (Austria) is a dedicated pharmacy professional with a strong academic background and practical experience in both hospital and community settings. She holds a bachelor’s in pharmacy from the University of Innsbruck, where she researched tocopherol’s effects on immune cells in asthma, and a master’s from Paracelsus Medical University, focusing on tryptophan metabolism in glioblastoma.
Her research skills include PCR, Western blotting, immunofluorescence, gene silencing, and molecular modeling.
Clinically, she manages medication therapies, counsels patients, prepares chemotherapy solutions, and ensures accurate drug dispensation. She is fluent in English, German, Dari, and Persian.
Her proven teamwork, resilience, and adaptability make her exceptionally well-suited to contribute meaningfully to collaborative research environments and to excel in the dynamic challenges of scientific inquiry.
Planned secondments: 2 months at CNIO for testing the impact of bioenergetics on RAG and TSC outcomes in vivo. 2 months at KU Leuven and 2 months at UMC Utrecht to conduct metabolic profiling of TSC cohorts. 3 months at Mimetas to test amino acid intervention on kidney on chip.
Spanish National Cancer Research Center
2 monthsMadrid, Spain
KU Leuven
2 monthsLeuven, Belgium
UMC Utrecht
2 monthsUtrecht, Netherlands
Mimetas
3 monthsLeiden, the Netherlands
My research project
Metabolic differences are promising non-genetic candidate modifiers of the disease course in mTORopathies. Disturbed energy metabolism has been reported in mouse and rat models of TSC, but it is unknown whether this observation translates to human patients. DC11 will be assess this in TSC cell models by fluxomics and quantitation of intra- and extracellular metabolites in response to changes in nutrient supply. Recruited scientist will test the impact of bioenergetics by modulating gene expression and by pharmacological targeting in vitro and in vivo. In patient cohorts, the PhD candidate will evaluate the correlation between nutrient levels in TSC individuals with disease burden related to brain and kidney function.
PhD enrolment : 
DC 10: Sara Owad